1 mouse is serial, 1 is USB and both work correctly. How can I set one up for left handed and the other for right handed. When I change mouse properties they both change and I would like one of each for the multiple users in the home. Can anyone help please?

What operating system?

Yea depending on the operating system you could just set up different user profiles. You can get instructions for this by clicking on Start/Help then looking for Users and then Adding Users. Windows 2000 you can add new users via control panel/users and passwords. But depending on your OS you can look in the help feature and get all the info you need.
Variable

OS used is WIN 98 if that helps any.

I think the only way is to:

1) Use different user profiles

2) The mice have to be different manufacturers so there will do different drivers and software....